RNA binding proteins (RBPs)
RBPs are truly multifaceted proteins that play critical roles in RNA biogenesis, function, stability, cellular localization and transport by influencing their structure and interactions. A great number of RBPs are produced in eukaryotic cells, each enclosing a unique protein-to-protein interaction characteristic and RNA-binding activity. The remarkable diversity of RBPs have increased during evolution; allowing eukaryotic cells to give rise to unique RNP for each RNA by utilizing a wide range of exclusive combinations. ZFP36L1 belongs to a zinc finger family of RNA binding protein, which are characterised by CCCH class of tandem zinc finger proteins. This zinc finger protein family recognises conserved Adenylate Uridylate rich elements (AREs) present in 3'untranslated regions (UTRs) of mRNAs and promote their degradation, ultimately leading to mRNAs decay. ZFP36 family are implicated in regulation of many ARE containing mRNAs, which encode for proteins related to development, cell differentiation, inflammation and apoptosis. Loss of ZFP36 family member expressions results in deregulation of several mRNA targets that have prominent role in regulation of oncogenes and tumour suppressor genes. Although, in the recent years with technology developing rapidly, there are RBPs where little about their functional relevance is known. Genetic and biochemical experiments alongside the use of bioinformatic analysis has revealed sequenced genomes which need to be explored further to fill the gaps in knowledge. Up till date, there has been an impressive progress in the discovery of RNA-binding motifs and RBPs mode of interaction with RNA however their structure, the location of these proteins and the precise arrangements of these proteins in the complex RNA assemblies of distinct cellular compartments is still a mystery.